General Information

The Clinical Laboratory Sciences program started in 1997 and belongs to the School of Health Professions of the Medical Sciences Campus, UPR. This program is designed to fit the needs of the working MedicalMaster in Clinical Laboratory Technologist professional. It offers an innovative educational experience in areas related to molecular diagnosis, administration of laboratory facilities, and clinical sciences, which allows our graduates to manage clinical laboratories, engage in research, conduct in-service training, and address problems of instrumentation and analytical procedures, among others. In addition, the program emphasizes the research component by requiring a research project with publishable results.

The aim of the program is to train students with expertise in current tools of administration, leadership, and quality assurance in the laboratory setting.

Duration of the Program/Meeting Hours

Students are admitted to the program only once a year and can begin graduate studies in August of the current academic year. The duration of the program is three years offered during evening hours from 5:00 pm – 9:00 pm and alternate Saturdays from 8:00 am – 12:00 pm. All regular students are expected to register in 6 semester credits.


The language of instruction is Spanish, although textbooks are mostly in English. Applicants are encouraged to contact the program for detailed information.

Admission Requirements

  • Qualified applicants must have earned a Baccalaurate degree or Post-Baccalaurate Certificate in Medical Technology from an accredited institution of higher learning and be certified by the Commonwealth of Puerto Rico or an equivalent professional accrediting agency.
  • Minimum general grade point average (GPA) of at least 2.75.
  • Applicants must submit the results of graduate entrance examination tests: EXADEP (Examen de Admisión a Estudios de Posgrado).  The test should be taken no later than February of the year you expect to be admitted. This is a standardized test that measures verbal reasoning, quantitative, and analytical abilities in Spanish and in English as a second language). The EXADEP must be taken within five calendar years of the application date.
  • Two letters of recommendation from a former professor and/or from an employer.
  • Two Official Transcripts from all the institutions that were attended.
  • A personal interview with the faculty.
  • MSc Application Form.
  • Non refundable Application fee.

Important Dates to Remember

  • Admission to the program is open until March 15 of each academic year.
  • The EXADEP Test should be taken no later than February of the year you expect to be admitted.

Registration Costs

Registration fee for the entire program (three years) is: $5,000.00 (this does not include:  facilities fess, graduation fees, ID card and health insurance among others). This amount can be paid as follows: First Year $2,000.00; Second Year $1,500.00 and Third Year $1,500.00. The student can apply for a payment extension.

Graduation Requirements

In order to graduate, students must:

  • Complete de 36 credit-hour program.
  • Obtain a minimum overall grade point average (GPA) of 3.00.
  • Complete the research project approved by the faculty.
  • Complete graduation requirements within a five-year period.

Course Descriptions

(Please click here to access the Medical Sciences Campus Catalog and look for the Course Descriptions for this Program)

Informative Sheet

(Please click here to download the Informative Sheet of the Program)

Graduate Courses

CILC 6008 – Advanced Clinical Hematology. Two (2) credits
The course provides medical technologists the opportunity to review basic concepts in Clinical Hematology and to acquire in depth knowledge of recent and emerging advances in the field. Emphasis will be placed on modern methods employed in laboratory diagnosis of leukemia/lymphoma, and selected blood coagulation disorders. Correlations of hematologic data will also be emphasized. Student presentations will center on modern theoretical concepts, technological innovations, and illustrative cases of clinical application. Laboratory exercises and/or demonstrations will be conducted.

CILC 6015 – Advanced Clinical Immunology Studies I. Two (2) credits
This course is designed to provide graduate students in Clinical Laboratory Science with knowledge of the immune responses against viral infections, the mechanisms of viral induced Immunopathology, and the diagnosis of several viral infections. Conferences will be offered on these principles followed by an independent study period where students analyze journal articles related to the previous conference. The presentation is focused on recent literature related to pathogenic mechanisms, and diagnosis of specific viral infections.

CILC 6016 – Advanced Clinical Immunology Studies II. Two (2) credits
This course will expose the Clinical Laboratory Sciences students to a general introduction in the Cancer Biology, the characteristics of the Cancer cells and their tumor products. The thematic content includes the following topics: origin, biochemistry, laboratory identification and quantification, and the clinical application of blood soluble and tissue tumor markers. A general overview of its value as clinical tools, tumor specificity and sensitivity, frequency of determination and cost effectiveness will also be discussed in this course. The themes will be presented utilizing the following instructional strategies: lectures, individual oral and written presentations, class discussion and other.

CILC 6019 – Clinical Laboratory Statistics. Two (2) credits
This course is designed to provide the graduate student of Clinical Laboratory Sciences with the knowledge, skills, and required attitudes for the application of statistical methods and procedures in the performance of the profession. This will lay a foundation in the description, analysis, and comparison of situation in the Clinical Laboratory daily work. These competences are essential to develop a professional capable of judging the validity and reliability of data and techniques, which support the research in their area of expertise. The thematic content includes: basic principles of statistical analysis, gathering, classification and report of data and sampling methodology. Emphasis is given to descriptive analysis of qualitative and quantitative variables, principles of probability, test of inferential analysis such as: regression and correlation; besides the non-parametrical statistics. The course will be offered by combined methodology of conference sessions, group discussions, and problem solving exercises, case studies and analysis of research papers.

CILC 6020 – Clinical Laboratory Management. Two (2) credits
This course is designed to provide medical technologists with an overview of their role as effective, and efficient laboratory managers. Emphasis is given to the administrative functions, basic skills for supervision and personnel administration. Students acquire the necessary knowledge to handle basic laboratory finances such as budget preparation, wage and salary administration and cost accounting among others. The principles of total quality management are discussed. The course enables the students to perform critical analysis of journal articles, oral presentations, case studies and group discussions.

CILC 6026 – Special Topics in Clinical Laboratory Administration. Two (2) credits
This course is designed to provide in depth coverage of special topics in administration, which had been discuss previously in other courses of the program. It also includes, relevant and current aspects of administration of clinical laboratories. The topics discussed are established by the faculty and others are suggested by the students considering their needs and experience. Due to the variability in content, this course could include any of the following instructional strategies: conferences, workshops, seminars, independent studies, and oral and written presentations.

CILC 6035 – Quality Assurance I. Two (2) credits
This course provides the graduate student of Clinical Laboratory Science with necessary knowledge for the application of quality management in the analytical process. Emphasis is given to the planning of a quality program, application and interpretation of statistics for the identification of variables that interfere with the quality of the result as required by the accrediting agencies. It considers the importance of quality in the pre-analytical, analytical, and post-analytical processes; also enables the graduate student to apply the quality monitoring and corrective measures to guarantee the excellence in the procedures. The topics are presented using the following educational strategies; lectures, discussions, oral presentations.

CILC 6036 – Quality Assurance II. Two (2) credits Pre-requisite: CILC 6035
This course provides the graduate students the knowledge required to perform a quality assurance program in the Clinical Laboratory in order to offer optimal services to the client. Tools needed to evaluate all the process involved in a clinical analysis, which includes specimen collection, handling, and analysis of the sample, and the communication between laboratory personnel, the patient and the doctor are discussed. It emphasizes in the actions and steps to follow when a situation that affects a test result is detected. The topics are presented through the following instructional strategies: lectures, discussions, presentations, and case studies. Course changed from 1 to 2 credits since January 2010.

CILC 6040 – Practice in Administration and Quality Assurance. Three (3) credits
This course offers the student the opportunity to apply the knowledge and skills acquired through the administration and quality assurance courses. Will perform an administrative evaluation of the areas in which the laboratory needs to improve. Of those deficient areas, the student will choose one of them to develop an action plan of corrective measurements and these will be implemented in coordination with the Laboratory Director. The instructional strategies used are practice, seminars, discussion, and oral presentations.

CILC 6046 – Genetics and Molecular Biology. Two (2) credits
The course is divided in two major areas. The first area in this course is molecular biology focused in the basic structure, properties and functions of nucleic acids and proteins. Topics discussed are DNA and RNA structure, replication, repair and recombination, DNA transcription, and RNA processing and translation. The second area is a survey of genetics. Within this area the following topics are presented: genetic terminology, patterns of inheritance and its variations in family and population level, genetic pedigree and its importance, and chromosome abnormalities and their relationship with disease. The clinical aspects of genetics, syndromes and prenatal diagnosis are presented. Topics will be presented through lectures, literature discussion and students’ presentations.

CILC 6055 – Fundamentals of Research Proposal Design. Two (2) credits
This course is designed to develop basic research skills in the Clinical Laboratory Science student in order to complete a feasible proposal for a research project in their major area of interest. Basic tools for scientific writing and presentations are also included. The instructional strategies will include: lectures, seminars, class discussions, literature review, and written and oral presentation of the proposal, among others.

CILC 6205 – Laboratory Information Systems and Informatics. Two (2) credits
This course is designed to provide students with a theoretical and practical knowledge of informatics in the laboratory. The course focuses in three areas; applications of informatics, databases and appropriate use of technology. The knowledge and skills acquired during this course will allow the laboratory professionals to maximize production, research and management in the laboratory. Laboratory sessions are included to complement the theory learned during the lectures.

CILC 6301 – Molecular Diagnostics I. Two (2) credits
Through lectures, group discussions, laboratory experiences and the interpretation of scientific papers, the course will present the basic principles of molecular diagnostics used in clinical and research laboratories. The student is exposed to advances in molecular diagnostics in industry and in research procedures. Topics to be discussed are: purification and quantification of DNA and RNA, gel electrophoresis, visible spectrophotometry of nucleic acids, restriction enzyme analysis of DNA, DNA amplification and optimization of Polymerase Chain Reaction (PCR) and real time PCR. The course will also present the topics of microarrays, quality control, assurance, and assay validations for molecular diagnostics and General Laboratory Practices (GLP´s) for the molecular diagnostics. Applications of these techniques in the molecular diagnosis of prevalent diseases will be discussed.

CILC 6302 – Molecular Diagnostics II. Two (2) credits
The course includes the theoretical aspects of peptide synthesis and purification, quality control and industrial and research applications. Hands on practices include the purification of proteins, HPLC chromatography, gas and ion exchange chromatography, and spectrometry. The course will also present the clinical applications of proteomics. The nature of protein biomarkers and the techniques for their discovery will also be discussed. Topics will be presented through lectures, open discussions and laboratory practices.

CILC 6305 – Clinical Laboratory Science Research. Three (3) credits
This course is designed so that the Clinical Laboratory Sciences student can apply basic research skills in order to perform and complete their approved research proposal. The student will be able to apply and integrate the scientific skills required for the execution of his/her research project as well as the writing skills required for manuscript preparation and submission for publication.

CILC 6306 – Pharmacogenomics: The Scientific Principles of Personalized Medicine. Two (2) credits
The course is divided in two major areas. The first area covers principles of pharmacogenetics and physiogenomics, including a review of existing molecular and statistical technologies. Topics discussed include pharmacokinetics and dynamics, technologies for biomarker discovery, and bioinformatics aspects of diagnostic systems. The second area concerns clinical applications across the real of medicine. Topics include case studies of the practice of individualized healthcare in infectious disease, oncology, endocrinology and metabolism, psychiatry and cardiology. Core areas of discussion include systems for discovery and clinical applications of biomarkers and the predictive value of these systems in clinical medicine. In addition the regulatory and ethical milieu of personalized medicine is discussed with case studies on various pharmaceutical and diagnostic products.

CILC 6400 – Seminar. Two (2) credits
This course provides for knowledge construction through the interaction among students, professors and researchers on critical discussion of relevant topics and new tendencies presented in recent literature and scientific research in topics related to molecular diagnostics and laboratory management, among others. Students will prepare written questions about methodology, interpretation of findings, and other relevant aspects regarding the research papers and topics presented in order to foster analysis and critical discussion. Students will also choose a topic in order to prepare a literature review and an oral presentation. The course includes guest speakers whom will present state of the art techniques and research topics, and also via students’ presentations of articles previously approved by the professor. Grading System: Passed (P), Not Passed (NP).

Program Faculty

Dr. Bárbara Segarra Vázquez, Dean of the School of Health Professions and Director
Prof. María T. San Martín, Associate Director
Dr. Margarita Irizarry Ramírez, Faculty Member

The program has an excellent pool of outstanding faculty members from different disciplines that have been with the program for more than five years. This faculty has high qualifications and is strongly committed to the goal of providing a balanced program of study designed to produce clinical laboratory scientists.

In addition to the teaching faculty, we have a cadre of distinguished mentors who have demonstrated commitment and scholarly productivity supporting the program’s goals and objectives and mentoring clinical research.

Physical Address

UPR-Medical Sciences Campus, School of Health Professions Building, Office 631, Rio Piedras, PR

Prof. María T. San Martín, Associate Director
(787) 758-2525 exts. 2712, 1689, 2600